Associate Professor, Department of Biomedical Engineering, The University of Melbourne
Quantification of change due to arthritis using micro-computed tomography imaging (clinical and preclinical) and novel image processing approaches.
4 Featured Manuscripts
Stok K, Burghardt A, Boutroy S, Peters M, Manske S, Stadelmann V, Vilayphiou N, Van Den Bergh J, Geusens P, Li X, Marotte H, et al. Consensus approach for 3D joint space width of metacarpophalangeal joints of rheumatoid arthritis patients using high-resolution peripheral quantitative computed tomography. Quantitative imaging in medicine and surgery. 2020; 10(2): 314-325. doi:10.21037/qims.2019.12.11
C. E. M. ter Voert, N. R. Y. Kour, B. van Teeffelen, N. Ansari, K. S. Stok, Contrast-enhanced micro-computed tomography of articular cartilage morphology with ioversol and iomeprol, J. Anat, 237(6):1062-71, 2020, 10.1111/joa.13271.
K. S. Stok, B. A. Besler, T. H. Steiner, A. V. Villarreal Escudero, M. A. Zulliger, M. Wilke, K. Atal, A. Quintin, B. Koller, R. Müller and D. Nesic. Three-dimensional quantitative morphometric analysis (QMA) for in situ joint and tissue assessment of osteoarthritis in a preclinical rabbit disease model, PLoS One, 11(1): e0147564, 2016
K. S. Stok, G. Pelled, Y. Zilberman, I. Kallai, D. Gazit, and R. Müller. Revealing the interplay of bone and cartilage in osteoarthritis through multimodal imaging of murine joints, Bone, 45:414-422, 2009.
CT in Research/Clinic
“In my research group, we employ computed tomography methods to help interpret how joints respond to stresses. This approach could ultimately allow us to predict someone’s risk of developing a musculoskeletal condition like arthritis.”
“My team have developed a first-of-its-kind quantitative morphometric analysis (QMA) software which can extract this data related to structural change that we can see from medical imaging like CT scans.”
Statement on OCTA Mission
“Given the multi-faceted characteristics of arthritis, it is critical to identify disease-specific features that disrupt joint homeostasis and cause tissue damage and disease onset. We do this using technologies like microCT.”