Assistant Professor, Research unit of medical imaging physics and technology, Faculty of Medicine, University of Oulu, Oulu, Finland
Research interests
Contrast-enhanced computed tomography, high-resolution CT and x-ray microscopy, image segmentation and machine learning, imaging biomarkers.
CT in research/clinic
My research aims to introduce novel methods to gain further information on microstructures from computed tomography in both research and clinical setting. In addition, I have established novel methods to allow high-resolution CT imaging of soft tissues.
Statement on OCTA mission
To raise awareness of computed tomography in osteoarthritis research from pre-clinical to clinical setting, standardize protocols, and inspire international collaborations to develop innovative imaging biomarkers for diagnostic imaging that could allow treatment monitoring.
Selected Publications
1. Rytky SJO, Huang L, Tanska P, Tiulpin A, Panfilov E, Herzog W, Korhonen RK, Saarakkala S, Finnilä MAJ. Automated analysis of rabbit knee calcified cartilage morphology using micro-computed tomography and deep learning. J Anat. 2021 Mar 29. doi: 10.1111/joa.13435. Epub ahead of print. PMID: 33782948.
2. Karhula SS, Finnilä MAJ, Rytky SJO, Cooper DM, Thevenot J, Valkealahti M, Pritzker KPH, Haapea M, Joukainen A, Lehenkari P, Kröger H, Korhonen RK, Nieminen HJ, Saarakkala S. Quantifying Subresolution 3D Morphology of Bone with Clinical Computed Tomography. Ann Biomed Eng. 2020 Feb;48(2):595-605. doi:10.1007/s10439-019-02374-2. Epub 2019 Oct 3. PMID: 31583552; PMCID: PMC6949315.
3. Kestilä I, Folkesson E, Finnilä MA, Turkiewicz A, Önnerfjord P, Hughes V, Tjörnstrand J, Englund M, Saarakkala S. Three-dimensional microstructure of human meniscus posterior horn in health and osteoarthritis. Osteoarthritis Cartilage. 2019 Dec;27(12):1790-1799. doi: 10.1016/j.joca.2019.07.003. Epub 2019 Jul 10. PMID: 31301431; PMCID: PMC7610688.
4. Ylitalo T, Finnilä MAJ, Gahunia HK, Karhula SS, Suhonen H, Valkealahti M, Lehenkari P, Haeggström E, Pritzker KPH, Saarakkala S, Nieminen HJ. Quantifying Complex Micro-Topography of Degenerated Articular Cartilage Surface by Contrast-Enhanced Micro-Computed Tomography and Parametric Analyses. J Orthop Res. 2019 Apr;37(4):855-866. doi: 10.1002/jor.24245. Epub 2019 Mar 5. PMID: 30737811; PMCID: PMC6518937.
5. Finnilä MAJ, Thevenot J, Aho OM, Tiitu V, Rautiainen J, Kauppinen S, Nieminen MT, Pritzker K, Valkealahti M, Lehenkari P, Saarakkala S. Association between subchondral bone structure and osteoarthritis histopathological grade. J Orthop Res. 2017 Apr;35(4):785-792. doi: 10.1002/jor.23312. Epub 2016 Jun 22. PMID: 27227565; PMCID: PMC5412847.
