Dr. George Varghese Professor of Rehabilitation Medicine
Medical Director of Musculoskeletal Rehabilitation
Director of Clinical Research, Rehabilitation Medicine
Director, Clinical Osteoarthritis Research Program
The University of Iowa College of Public Health
Adjunct Professor, Epidemiology
Research Interests
Risk factors for development and worsening osteoarthritis
Weight-bearing joint imaging
Rehabilitation interventions for musculoskeletal disease
CT in Research
Using diagnostic imaging to identify factors which predict who will develop osteoarthritis structural disease and symptoms as well as evaluating preventive interventions through clinical trials. The long-term goals of my research program are to reduce risk for disablement due to osteoarthritis and other lower limb musculoskeletal problems.
Statement on OCTA Mission
Advance understanding of how CT can be used to expedite identification or risk for and treatment of osteoarthritis
Selected Publications
1. Segal NA, Nevitt MC, Lynch JA, Niu J, Torner JC, Guermazi A. Diagnostic performance of 3D standing CT imaging for detection of knee osteoarthritis features. Phys Sportsmed 2015; 43: 213-220. [doi:10.1080/00913847.2015.1074854] {PMC4818011} https://www.ncbi.nlm.nih.gov/pubmed/26313455
2. Segal NA, Frick E, Duryea J, Roemer F, Guermazi A, Nevitt MC, Torner JC, Felson DT, Anderson DD. Correlations of Medial Joint Space Width on Fixed-Flexed Standing Computed Tomography and Radiographs with Cartilage and Meniscal Morphology on Magnetic Resonance Imaging. Arthritis Care Res (Hoboken) 2016; 68: 1410-1416. [doi:10.1002/acr.22888] {PMC5027176} https://www.ncbi.nlm.nih.gov/pubmed/26991547
3. Segal NA, Bergin J, Kern A, Findlay C, Anderson DD. Test-retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner. Skeletal Radiol 2017; 46: 217-222. [doi:10.1007/s00256-016-2539-8] {PMC5179299} https://www.ncbi.nlm.nih.gov/pubmed/27909787
4. Segal NA, Frick E, Duryea J, Nevitt MC, Niu J, Torner JC, Felson DT, Anderson DD. Comparison of tibiofemoral joint space width measurements from standing CT and fixed flexion radiography. J Orthop Res 2017; 35: 1388-1395. [doi:10.1002/jor.23387] {PMC5299055} https://www.ncbi.nlm.nih.gov/pubmed/27504863
6. Kothari MD, Rabe KG, Anderson DD, Nevitt MC, Lynch JA, Segal NA, Franz H, Multicenter Osteoarthritis Study G. The Relationship of Three-Dimensional Joint Space Width on Weight Bearing CT With Pain and Physical Function. J Orthop Res 2019: 1–7. [doi:10.1002/jor.24566], https://www.ncbi.nlm.nih.gov/pubmed/31840831
