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CT in OA Research Blog

pQCT Subchondral Bone Imaging

1/18/2021

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Andy Kin On Wong, PhD

Scientist, Joint Department of Medical Imaging, UHN 
Assistant Professor, Epidemiology, DLSPH, University of Toronto

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Peripheral quantitative computed tomography (pQCT) has been used to measure subchondral BMD of the knee. 
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Although pQCT model XCT2000 has a limited gantry diameter, it can still accommodate most individuals with BMI≤ 30 kg/m2. XCT3000 has a larger gantry able to accommodate most knees even for individuals with higher BMI. 
Bennell previously examined subchondral BMD at the 2% and 4% tibial plateau relative to a reference line placed at a level between medial and lateral tibial compartments’ most radio-opaque plateau regions. No femoral condyles were examined, and if compartments were misaligned from the scanner’s Z-axis, the compartment-specific analyses would be oblique.
https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.23795

Whyte presented alternative protocols suggesting 4 individual reference lines for each of medial and lateral tibial and femoral condyles, then using 1% relative distance for tibial plateaus and 2% relative distance for femoral condyles – to account for differences in regions of interests. 
  • Tibial plateau 1% region avoiding the cortex in most cases. 
  • Femoral condyle 2% region avoiding the cortex and permitting a substantial amount of trabecular bone for analysis. ​
See protocol comparison poster in downloadable PDF below– presented in 2019 at QMSKI in Calgary, AB, Canada. 
Rachel Whyte Comparison of pQCT Subchondral Bone Imaging Protocols.pdf
File Size: 9403 kb
File Type: pdf
Download File

Subchondral regions of interests marked by periosteal perimeters inset by 20% and total BMD computed to yield subchondral BMD for each compartment. ​
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The results of test-retest precision for Protocol 3 applied to healthy and diseased patients, demonstrating sufficient test-retest precision for subchondral BMD measurements overall: ​
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  • Home
  • Gallery
  • Research
    • Featured Research
  • Videos
  • Executive Committee
    • Dr. MIkko A.J. Finnilä
    • Dr. Sarah Manske
    • Dr. Neil Segal
    • Dr. Kathryn Stok
    • Dr. Tom Turmezei
    • Dr. Andy Kin On Wong
  • Membership
  • Contact